Its use during lactation is also generally advised against, but a small trial found that infants breastfed by mothers taking tramadol were exposed to about 2.88% of the dose the mothers were taking. No evidence of this dose having a harmful effect on the newborn was seen. The determination of the pharmacokinetic parameters of tramadol in plasma and a better characterization of its metabolites after oral administration to horses is necessary to design dosage. Tramadol is an opioid analgesic used for the therapy of mild-to-moderate pain. Tramadol overdose can cause acute liver failure. Pharmacologic use of tramadol has not been associated with cases of clinically apparent drug induced liver disease. Tramadol hydrocholoride is a medication used for pain control in humans due to its opioid effects on the central nervous system. At the current time in the veterinary world, it is used primarily. I used to work with horses & I miss it loads I also was a market trader for 6 years & a biker. It is tough to live with, but the right meds do help - I have Tramadol for pain & Amitriptyline for my muscle spasms & sleep problems. Also the use of a good diary & a calender is helpful you may get a bit forgetful. I had to use my hands and arms to get up out of bed. My body has been pushed as far as it will go. So after trying all my best tricks (aminos, coffee, food, vitamins, water) I finally stopped the struggle and called in sick for work. Tomorrow will be a busier day anyhow. Tramadol hydrocholoride is a medication used for pain control in humans due to its opioid effects on the central nervous system. At the current time in the veterinary world, it is used primarily. The determination of the pharmacokinetic parameters of tramadol in plasma and a better characterization of its metabolites after oral administration to horses is necessary to design dosage regimens to achieve target plasma concentrations that are associated with analgesia. Common human painkiller may be effective for horses March 7, 2007 A study is holding out hope that a common prescription painkiller may prove to be a very effective painkiller for horses. Pythiosis (Oomycosis, Lagenidiosis, Swamp Cancer, Bursatti, Leeches) in Dogs, Cats and Horses Rabies in Animals Renal Anemia, or Inadequate Red Blood Cells, in Dogs and Cats.